International Journal of Engineering and Techniques – Volume 6 Issue 1, January 2020ELECTROCHEMICAL BIOSENSORS AND TRANSDERMALDRUG DELIVERY SYSTEM AS AN APPROACH TODIAGNOSE AND TREAT HYPERTENSIVE HEART DISEASEA REVIEWNilakshi Mazumder1, Diksha Gupta2, Minika Chetry3 and Shilpa Sivashankar*Department of Biotechnology,Acharya Institute of Technology, Affiliated to Visvesvaraya Technological University (VTU),Soladevanahalli, Bengaluru, Karnataka-560107, India.*corresponding author: s shilpa@acharya.ac.in; ssshilpashiva9@gmail.com1Co-author: n ilakshi.bebt.16@acharya.ac.in2Co-author: d iksha.bebt.16@acharya.ac.in3Co-author: m inika.bebt.16@acharya.ac.i

ABSTRACT
Developing countries are in immense need of portable and easy-to-use diagnostic tools because of the lack of access
to sophisticated diagnostic centres in the villages and underdeveloped areas. Hypertensive Heart Disease is a serious
health ailment, which results in various cardiac disorders, stroke and other severe cases that may result in the damage
of the kidney, brain, liver, thereby, causing multiple organ damage. A few biomarkers related to the Hypertensive
Heart Disease are easily found in the blood and urine. The detection techniques used at present are expensive, and
detect the prevalence of the disease only after the occurrence of a few signs and symptoms. We thereby, present a
review on biosensors that would be cost-effective for detection of the disease. Electrochemical biosensors detect the
concentrations of the biomarkers that are present in the biological fluids to confirm the prevalence of the disease.
Once the biomarker concentrations cross the threshold value, the disease is confirmed, which then needs to be treated.
The treatment for the disease could employ Transdermal Drug Delivery System, which serves to be one of the most
convenient methods of drug administration. We hence present a review of Electrochemical Biosensors that could
detect Hypertensive Heart Disease and the Transdermal Drug Delivery System, which could be used for the treatment
of the disease.
Keywords: Hypertensive Heart Disease; electrochemical biosensor; transdermal drug delivery system